Assorted vtubers like Nyanners, Omaru Polka, Pikamee, Artemis of the Blue, and more
Vtubers are a combination of someone playing a character and being themselves all at once while playing games, doing reaction content, etc, and of course like any lets player how much you'll enjoy them depends on your preference in games or personality (some people may prefer the bubbly personality of someone like Nene, while others might prefer the laid back Botan).
Matt McMuscles
Formerly of Super Best Friends Play, Matt has a successful solo channel where he still does lets plays, but also has the highly informative and entertaining "Wha Happun?", which covers mainly the making of various games and movies (both good and bad, but most of the time the bad ones).
GVMERS
Gaming documentary channel that feels akin to G4's old "Icons" show, goes pretty in depth in the history of various games and franchises (most popular is their "rise and fall" series which covers franchises that were once big hits and the unfortunate ends most of them ended up having, like Dead Space and Silent Hill).
Rebel Taxi/PanPizza
Reviewer who mainly covers animation but also occasionally branches out into videos on live action or video games. Covers cartoons both new and old, and it is thanks to him I got interested in checking out stuff like Bojack Horseman.
Saberspark
Another reviewer who mainly covers animation. Has carved out a certain niche where he likes covering obscure animated media, especially stuff that's pretty raunchy and often contains anthro characters.
penguinz0
Aka Critikal. Originally followed him for his old lets plays where his commentary hit this amusing spot of being both very dry but crude all at once. Still watch him for his assorted improv comedy stuff and his commentary videos. Not always in 100% agreement with the dude and I can understand if his style of humor maybe gets a bit too repetitive, but dude's got a certain charm that keeps me coming back.
Nexpo, Night Mind, ReignBot, Lazy Masquerade, and Shrouded Hand
Lumping these together since they cover similar topics. All are channels focused on horror and cover topics like internet mysteries, alternate reality games or series, or true crime topics like unsolved murders.
Dwars
Small time lets player who occasionally also does review videos. Main focus for him is shooters that either are actually old or at least replicate the look and feel of old shooters (aka "boomer shooters").
Civvie 11
Shooter focused reviewer with an entertaining sense of humor, often compared to both Ross Scott of Freeman's Mind fame or The Spoony One back when Spoony was still considered good. Has a framing device for his videos where he acts like he's a prisoner locked away deep underground for reasons unknown.
MandaloreGaming
Reviewer who mostly covers more obscure games, his content is well edited and much of his humor manages to land with me. Its thanks to him I checked out stuff like Warhammer 40K: Mechanicus, Paratopic, and the Pathologic series.
Berd
Most of his videos are just animated shitposts and I find them pretty amusing.
There are many more I could go on about but I'll end it here for now.